A pentaacetylated derivative of quercetin with diverse biological activities; scavenges DPPH radicals in vitro (IC50 = 3.74 μg/ml); inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml); inhibits LPS-induced increases in nitrite production (IC50 = 8.7 μM) and PGE2 production

Pentaacetylquercetin – 10 mg

Brand:
Cayman
CAS:
1064-06-8
Storage:
-20
UN-No:
- /

Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin (Item No. 10005169) that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.{45115,45116,45117} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml).{45115} Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 (Item No. 14010) production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM.{45116} It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively).{45117}  

 

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Description

A pentaacetylated derivative of quercetin with diverse biological activities; scavenges DPPH radicals in vitro (IC50 = 3.74 μg/ml); inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml); inhibits LPS-induced increases in nitrite production (IC50 = 8.7 μM) and PGE2 production, as well as iNOS and COX-2 levels, in RAW 264.7 cells at 20 and 40 μM; inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively)

Formal name: 3,5,7-tris(acetyloxy)-2-[3,4-bis(acetyloxy)phenyl]-4H-1-benzopyran-4-one

Synonyms:  NSC 115919|Peracetylated Quercetin|Quercetin Pentaacetate

Molecular weight: 512.4

CAS: 1064-06-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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