A chelating agent; increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day; dissolves copper-rich granules in hepatic lysosomes of LEC rats (100 mg/kg per day); has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg

Penicillamine – 10 g

Brand:
Cayman
CAS:
52-67-5
Storage:
-20
UN-No:
Non-Hazardous - /

Penicillamine is an orally bioavailable copper chelator and penicillin degradation product.{40699,40700} It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels.{40701} Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene.{40702} Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME (Item No. 80210) and 7-nitroindazole (Item No. 81340).{40703} Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.  

 

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Description

A chelating agent; increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day; dissolves copper-rich granules in hepatic lysosomes of LEC rats (100 mg/kg per day); has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the NOS inhibitors L-NAME and 7-nitroindazole

Formal name: 3-mercapto-D-valine

Synonyms:  D-Penicillamine|NSC 81549|β-Thiovaline

Molecular weight: 149.2

CAS: 52-67-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Metal Chelators||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Neuroscience|Seizure Disorders

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