A typical antipsychotic; binds to dopamine receptors (IC50 = 5.6 nM); binds to dopamine D4 and 5-HT receptors (Kis = 31 and 63.1 nM

Penfluridol – 250 mg

Brand:
Cayman
CAS:
26864-56-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.  

 

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SKU: 26071 - 250 mg Category:

Description

A typical antipsychotic; binds to dopamine receptors (IC50 = 5.6 nM); binds to dopamine D4 and 5-HT receptors (Kis = 31 and 63.1 nM, respectively); inhibits stereotypic behavior induced by apomorphine in cynomolgus monkeys at 1.25 and 2.5 mg/kg; inhibits proliferation of TNBCs (IC50s = 6-8 µM); inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4; reduces tumor growth and metastasis in a 4T1 orthotopic mouse model at 10 mg/kg per day

Formal name: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol

Synonyms:  R-16341

Molecular weight: 524

CAS: 26864-56-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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