An antiviral guanosine analog; has activity against multiple laboratory and clinical isolate strains of HSV-1

Penciclovir – 500 mg

Brand:
Cayman
CAS:
39809-25-1
Storage:
-20
UN-No:
Non-Hazardous - /

Penciclovir is a guanosine analog with antiviral activity.{41028} It has activity against multiple laboratory and clinical isolate strains of herpes simplex virus 1 (HSV-1), HSV-2, and varicella zoster virus (VZV) in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml). Penciclovir inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells.{41028},{41029} In vivo, topical and systemic administration of penciclovir reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice.{41030} It also prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally.  

 

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SKU: 22918 - 500 mg Category:

Description

An antiviral guanosine analog; has activity against multiple laboratory and clinical isolate strains of HSV-1, HSV-2, and VZV in a plaque reduction assay (IC50s = 0.4-3.1 μg/ml); inhibits HSV-1 and HSV-2 replication (IC99s = 0.4 and 0.7 μg/ml, respectively) and DNA synthesis (IC50 = 0.04 μg/ml) in MRC-5 cells; reduces the severity of skin lesions caused by HSV-1 in guinea pigs and mice; prevents development of HSV-2-induced genital lesions in guinea pigs infected intravaginally

Formal name: 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one

Synonyms:  BRL 39123

Molecular weight: 253.3

CAS: 39809-25-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Chicken Pox & Shingles||Research Area|Infectious Disease|Viral Diseases|HSV

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