An alkaloid with diverse biological activities; increases LC3B-II protein levels and induces cell death in HCT116 colorectal carcinoma cells in a concentration-dependent manner; reduces tumor growth in an HCT116 mouse xenograft model at 3 mg/kg every other day; has antitussive effects in a mouse cough model induced by ammonia liquor at3 mg/kg; reduces dermal and epidermal thickness

Peiminine – 10 mg

Brand:
Cayman
CAS:
18059-10-4
Storage:
-20
UN-No:
Non-Hazardous - /

Peiminine is an alkaloid that has been found in Fritillaria and has diverse biological activities.{53419,53420,53421} It increases protein levels of the autophagy marker LC3B-II and induces cell death in HCT116 colorectal carcinoma cells in a concentration-dependent manner.{53419} Peiminine (3 mg/kg every other day) reduces tumor growth in an HCT116 mouse xenograft model. It has antitussive effects in a mouse cough model induced by ammonia liquor when administered at a dose of 3 mg/kg.{53420} Peiminine (5 mg/kg) reduces dermal and epidermal thickness, inhibits dermal infiltration of eosinophils and mast cells, and decreases serum levels of IgE, IL-4, and TNF-α in a mouse model of atopic dermatitis induced by dinitrochlorobenzene (DNCB).{53421}  

 

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SKU: 29618 - 10 mg Category:

Description

An alkaloid with diverse biological activities; increases LC3B-II protein levels and induces cell death in HCT116 colorectal carcinoma cells in a concentration-dependent manner; reduces tumor growth in an HCT116 mouse xenograft model at 3 mg/kg every other day; has antitussive effects in a mouse cough model induced by ammonia liquor at3 mg/kg; reduces dermal and epidermal thickness, inhibits dermal infiltration of eosinophils and mast cells, and decreases serum levels of IgE, IL-4, and TNF-α in a mouse model of DNCB-induced atopic dermatitis at 5 mg/kg

Formal name: (5α)-3β,20-dihydroxy-cevan-6-one

Synonyms:  Verticinone

Molecular weight: 429.6

CAS: 18059-10-4

Purity: ≥98%

Formulation: A solid

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