A broad-spectrum and synthetic fluoroquinolone antibiotic; active against clinical isolates of E. coli

Pefloxacin (mesylate hydrate) – 10 g

Brand:
Cayman
CAS:
149676-40-4
Storage:
-20
UN-No:
Non-Hazardous - /

Pefloxacin is a broad-spectrum and synthetic fluoroquinolone antibiotic and a methylated derivative of norfloxacin (Item No. 25975).{47756,47757} It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, S. aureus, and G. vaginalis (MIC90s = 0.12, 0.5, 0.5, and 32 mg/L, respectively).{47756,47757} Pefloxacin selectively inhibits E. coli topoisomerase I and DNA gyrase over calf thymus topoisomerase I (IC50s = 45, 4.5, and >140 μg/ml, respectively) in cell-free assays.{47758} In vivo, pefloxacin is active against systemic E. coli, K. pneumoniae, and P. aeruginosa infections in mice with 50% of efficacy maximum (P50) values of 6.5, 29.2, and 219 mg/kg, respectively.{47759}  

 

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SKU: 29103 - 10 g Category:

Description

A broad-spectrum and synthetic fluoroquinolone antibiotic; active against clinical isolates of E. coli, K. pneumoniae, S. aureus, and G. vaginalis (MIC90s = 0.12, 0.5, 0.5, and 32 mg/L, respectively) selectively inhibits E. coli topoisomerase I and DNA gyrase over calf thymus topoisomerase I (IC50s = 45, 4.5, and >140 μg/ml, respectively) in cell-free assays; active against systemic E. coli, K. pneumoniae, and P. aeruginosa infections in mice (P50s = 6.5, 29.2, and 219 mg/kg, respectively)

Formal name: 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate, dihydrate

Synonyms: 

Molecular weight: 465.5

CAS: 149676-40-4

Purity: ≥98%

Formulation: A solid

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