A ceramide analog that contains a mixture of all four possible stereoisomers; inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates and inhibits β-1

PDMP (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
73257-80-4
Storage:
-20
UN-No:
Non-Hazardous - /

PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.{11392} PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all four of these stereoisomers. PDMP inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates, however, the ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer.{11393} The D-threo PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} PDMP enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro.{42422}  

 

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Description

A ceramide analog that contains a mixture of all four possible stereoisomers; inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates and inhibits β-1,4-galactosyltransferase 6, however, the inhibitory activity on both enzymes is attributed to the D-threo enantiomer; enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro

Formal name: N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride

Synonyms:  DL-erythro/threo-PDMP

Molecular weight: 427

CAS: 73257-80-4

Purity: ≥98%

Formulation: A crystalline solid

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