An inhibitor of Chk1 and WEE1 (IC50s = 47 and 97 nM

PD 407824 – 10 mg

Brand:
Cayman
CAS:
622864-54-4
Storage:
-20
UN-No:
Non-Hazardous - /

PD 407824 is an inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively).{37766} It is selective for Chk1 and WEE1 over PKC (IC50 = 3.4 µM), Cdk4 (IC50 = 3.75 µM), as well as c-Src and the PDGF and FGF receptors (IC50s = >50 µM for all), and other Cdks (IC50s = >50 µM).{37767} PD 407824 sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin when used at a concentration of 0.5 µM.{37768} It also sensitizes C2C12 myoblasts to bone morphogenic protein 4 (BMP4) and, when used in combination with BMP4, inhibits myotube formation and induces myoblasts to differentiate into mature osteoblasts.{37769} PD 407824, in combination with BMP4, induces human embryonic stem cells to differentiate into cells with mesoderm or cytotrophoblast stem cell lineages.  

 

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SKU: 25989 - 10 mg Category:

Description

An inhibitor of Chk1 and WEE1 (IC50s = 47 and 97 nM, respectively); selective for Chk1 and WEE1 over PKC (IC50 = 3.4 µM) and Cdk4 (IC50 = 3.75 µM); selective for Chk1 and WEE1 over c-Src and the PDGF and FGF receptors (IC50s = >50 µM for all), and other Cdks (IC50s = >50 µM); sensitizes SK-OV-3 and OVCAR-3 ovarian cancer cells, as well as cisplatin-resistant A2780cis cells, to cisplatin at 0.5 µM; induces myoblast differentiation into mature osteoblasts and hESC differentiation into cells with mesoderm or cytotrophoblast stem cell lineages when used in combination with BMP4

Formal name: 9-hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

Synonyms: 

Molecular weight: 328.3

CAS: 622864-54-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Checkpoint Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Stem Cell Research|Differentiation

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