A potent and selective inhibitor of MEK1/2 (IC50 = 10-100 nM)

PD 184161 – 1 mg

Brand:
Cayman
CAS:
212631-67-9
Storage:
-20
UN-No:
Non-Hazardous - /

The mitogen-activated protein (MAP) kinase intracellular signaling pathways are involved in the regulation of various cellular functions.{17156} One of these pathways, the Raf/MEK/ERK pathway, plays a major role in the regulation of cellular growth, differentiation, and proliferation. The modulation of this cascade has been studied as a useful approach to treating proliferative disorders such as cancer.{15421,15629} PD 184161 is a potent and selective inhibitor of MEK1/2 with an IC50 value that ranges from 10-100 nM. {15628} More effective at inhibiting phosphorylation of ERK1/2 than the selective MEK inhibitors, PD 098059 and U0126, PD 184161 is useful both in vitro and in vivo for studying the pharmacological role of the Raf/MEK/ERK pathway.{15628} PD 184161 is structurally related to clinically-studied MEK inhibitors PD184352 (CI-1040) and PD 325901 and has been shown to inhibit cell proliferation, induce apoptosis, and possess antitumor activity in MEK-dependent cancers.{15628}  

 

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SKU: 10012431 - 1 mg Category:

Description

A potent and selective inhibitor of MEK1/2 (IC50 = 10-100 nM)

Formal name: 5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide

Synonyms: 

Molecular weight: 557.6

CAS: 212631-67-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling

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