An broad-spectrum MMP inhibitor (IC50s = 6.1

PD 166793 – 5 mg

Brand:
Cayman
CAS:
199850-67-4
Storage:
-20
UN-No:
Non-Hazardous - /

PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively).{39768} It reverses peroxynitrite-induced decreases in contraction cease time, a measure of cardiac contractility, in isolated rat ventricular myocytes when used at a concentration of 2 μM.{39769} In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure.{39770} It reduces LV dilation and preserves systolic function in a rat model of progressive heart failure.{39768} PD 166793 also inhibits age-associated increases in aortic gelatinase and interstitial collagenase activity and mean arterial pressure in rats.{39771}  

 

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SKU: 23762 - 5 mg Category:

Description

An broad-spectrum MMP inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP13CD, and MMP-14CD, respectively); reverses peroxynitrite-induced decreases in contraction cease time in isolated rat ventricular myocytes at 2 μM; reduces LV peak wall stress in a porcine model of congestive heart failure at 2 mg/kg per day; reduces LV dilation and preserves systolic function in a rat model of progressive heart failure; inhibits age-associated increases in aortic gelatinase and interstitial collagenase activity and mean arterial pressure in rats,

Formal name: N-[(4′-bromo[1,1′-biphenyl]-4-yl)sulfonyl]-L-valine

Synonyms: 

Molecular weight: 412.3

CAS: 199850-67-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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