A reversible inhibitor of the auto and transphosphorylation kinase activity of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM)

PD 158780 – 5 mg

Brand:
Cayman
CAS:
171179-06-9
Storage:
-20
UN-No:
Non-Hazardous - /

PD 158780 is a pyridopyrimidine derivative that reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM), ErbB2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM).{28641} It does not inhibit PDGF or FGF-mediated tyrosine phosphorylation.{28641} At 0.5 µM, PD 158780 has been shown to induce G1 cell cycle arrest in MCF10A breast cancer cells.{28642}  

 

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Description

A reversible inhibitor of the auto and transphosphorylation kinase activity of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM), ErbB-2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM); induces G1 cell cycle arrest in MCF10A breast cancer cells

Formal name: N4-(3-bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine

Synonyms: 

Molecular weight: 330.2

CAS: 171179-06-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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