A potent

PD 153035 – 10 mg

Brand:
Cayman
CAS:
153436-54-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

PD 153035 is a potent, reversible inhibitor of EGFR kinase (Ki = 5.2 pM; IC50 = 29 pM).{23693} It less effectively inhibits HER2 (IC50 = 2.3 µM) and has little effect on several other receptor and non-receptor tyrosine kinases.{23693} PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.{23692,23691}  

 

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Description

A potent, selective, reversible inhibitor of epidermal growth factor receptor (EGFR) kinase (Ki = 5.2 pM; IC50 = 29 pM); rapidly suppresses autophosphorylation of EGFR in fibroblasts and human epidermoid carcinoma cells

Formal name: N-(3-bromophenyl)-6,7-dimethoxy-4-quinazolinamine

Synonyms:  AG-1517|NSC 669364|SU 5271

Molecular weight: 360.2

CAS: 153436-54-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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