Description
An inhibitor of calpain 1 (Ki = 0.26 µM); 20-fold selective for calpain 1 over calpain 2 (Ki = 5.33 µM); selective over cathepsin B, papain, trypsin, and thermolysin, (Kis = >200, >500, >500, and >500 µM, respectively); does not inhibit basal calcineurin activity (Ki = >200 µM) but does inhibit calmodulin-induced calcineurin activity (Ki = 84.54 µM); increases intracellular calcium in isolated human neutrophils and HEK293 cells expressing hFPRL1 at 10 µM
Formal name: 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid
Synonyms:
Molecular weight: 237.2
CAS: 179461-52-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes
