A potent agonist of the D3 receptor (Ki = 1 nM); shows selectivity for D3 over D2 and D4 receptors (Kis = 1.2 and 7 µM

(+)-PD 128907 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
300576-59-4
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-PD 128907 is a potent agonist of the dopamine 3 (D3) receptor (Ki = 1 nM).{33953,33956} It shows selectivity for D3 over D2 and D4 receptors (Kis = 1.2 and 7 µM, respectively).{33953} Low doses of (+)-PD 128907 (13 µg/kg, s.c.) reduce spontaneous locomotor activity in rats.{33954} It blocks stereotypy induced by the NMDA receptor antagonist (+)-MK-801 (Item No. 10009019) in mice.{33957} (+)-PD 128907 is used in animal models to study the role of the D3 receptor in nervous system disorders, such as schizophrenia, Parkinson’s disease, and depression.{31907,33955}  

 

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Description

A potent agonist of the D3 receptor (Ki = 1 nM); shows selectivity for D3 over D2 and D4 receptors (Kis = 1.2 and 7 µM, respectively); reduces spontaneous locomotor activity in rats

Formal name: 3,4,4aR,10bR-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol, monohydrochloride

Synonyms: 

Molecular weight: 285.8

CAS: 300576-59-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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