An inhibitor of EGFR

PD 089828 – 5 mg

Brand:
Cayman
CAS:
179343-17-0
Storage:
-20
UN-No:
Non-Hazardous - /

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 µM).{38888} It is selective for these targets over insulin receptor tyrosine kinase, PKC, and CDK4 (IC50s = >50 µM) but does inhibit MAPK (IC50 = 7.1 µM). PD 089828 decreases PDGF-BB-, EGF-, and bFGF-induced phosphorylation of PDGFR, EGFR, and FGFR1, respectively, in a concentration-dependent manner in vitro. It also decreases serum-stimulated growth (IC50 = 1.8 µM after 8 days) and migration (IC50 = 4.5 µM) of rat aortic smooth muscle cells.  

 

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Description

An inhibitor of EGFR, PDGFβ, FGF, and c-Src (IC50s = 0.15, 1.76, 5.47, and 0.18 µM, respectively); inhibits MAPK (IC50 = 7.1 µM); selective over insulin receptor tyrosine kinase, PKC, and CDK4 (IC50s = >50 µM); decreases PDGF-BB-, EGF-, and bFGF-induced phosphorylation of PDGFR, EGFR, and FGFR1 in vitro; decreases serum-stimulated growth (IC50 = 1.8 µM after 8 days) and migration (IC50 = 4.5 µM) of rat aortic smooth muscle cells

Formal name: N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N’-(1,1-dimethylethyl)-urea

Synonyms:  EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor

Molecular weight: 405.3

CAS: 179343-17-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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