A specialized pro-resolving mediator; increases macrophage numbers and phagocytic activity and decreases the resolution phase by 57% in an acute microbial-induced peritonitis model of inflammation in mice; reduces the levels of PGE2

PCTR1 – 10 µg

Brand:
Cayman
CAS:
1810710-59-8
Storage:
-80
UN-No:
Non-Hazardous - 1170 / 3

Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310).{38180} DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase.{38180,38178} PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice.{38179} PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It also reduces the levels of PGE2 (Item No. 14010), PGD2 (Item No. 12010), and TXB2 (Item No. 19030) in peritoneal exudates.  

 

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Description

A specialized pro-resolving mediator; increases macrophage numbers and phagocytic activity and decreases the resolution phase by 57% in an acute microbial-induced peritonitis model of inflammation in mice; reduces the levels of PGE2, PGD2, and TXB2 in peritoneal exudates,

Formal name: (4Z,7Z,10Z,12E,14E,16R,17S,19Z)-16-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-17-hydroxydocosa-4,7,10,12,14,19-hexaenoic acid

Synonyms:  Protein Conjugates in Tissue Regeneration 1

Molecular weight: 649.8

CAS: 1810710-59-8

Purity: ≥96%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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