Immunogen: Purified recombinant human PCSK9 • Host: Rabbit· Species Reactivity: (+) Human

PCSK9 (human) Polyclonal Antibody – 1 ea

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Cayman
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PCSK9 is a member of the subtilisin serine protease family with an important role in low-density lipoprotein (LDL) metabolism.{13178} Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia which is characterized by an increase in LDL cholesterol levels.{13158} PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through acceleration of the degradation of the LDL receptor.{13176,13178} PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscles with the highest expression in the liver.{13136} Human PCSK9 precursor is 692 amino acids in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein of 63 kDa in the Golgi.{13177}  

 

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SKU: 10240 - 1 ea Category:

Description

Immunogen: Purified recombinant human PCSK9 • Host: Rabbit· Species Reactivity: (+) Human, mouse, and rat • Application: WB

Synonyms: NARC-1|Proprotein Convertase Subtilisin Kexin 9

Immunogen: Purified recombinant human PCSK9

Formulation: 500 µg of Protein A-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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