A potent HDAC8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1

PCI 34051 – 5 mg

Brand:
Cayman
CAS:
950762-95-5
Storage:
-20
UN-No:
Non-Hazardous - /

PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively).{21341} PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 – 4 μM), but not in other hematopoietic or solid tumor lines.{21341} This compound has also been used to support a critical role for HDAC8 in the coordinated deacetylation of the core cohesion component SMC3 during mitosis.{21527}  

 

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SKU: 10444 - 5 mg Category:

Description

A potent HDAC8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively); induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 – 4 μM)

Formal name: N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide

Synonyms: 

Molecular weight: 296.3

CAS: 950762-95-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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