A pan-HDAC inhibitor (Kis = 7

PCI 24781 – 1 mg

Brand:
Cayman
CAS:
783355-60-2
Storage:
-20
UN-No:
Non-Hazardous - /

PCI 24781 is an HDAC inhibitor that predominantly targets HDAC1 with a Ki value of 7 nM.{32732} It inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 with Ki values of 19, 8.2, 17, 280, and 24 nM, respectively.{32732} PCI 24781 can prevent the growth of tumor cells in vitro, inducing apoptosis, as well as in mice harboring HCT116 or DLD-1 colon tumor xenografts.{32732}  

 

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SKU: 20059 - Category:

Description

A pan-HDAC inhibitor (Kis = 7, 19, 8.2, 17, 280, and 24 nM for HDAC1, HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10, respectively; prevents the growth of tumor cells in vitro, inducing apoptosis, as well as in mice harboring HCT116 or DLD-1 colon tumor xenografts

Formal name: 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide

Synonyms:  CRA-024781|CRA-24781

Molecular weight: 397.4

CAS: 783355-60-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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