An antibiotic with antimycobacterial activity; an irreversible inhibitor of DprE1; active against M. tuberculosis in vitro (MIC = ≤0.19 ng/ml) without inducing cytotoxicity in Vero cells at 125 µM; reduces the bacterial burden in the lung and spleen in a mouse model of chronic tuberculosis at 50 mg/kg per day

PBTZ169 – 25 mg

Brand:
Cayman
CAS:
1377239-83-2
Storage:
-20
UN-No:
Non-Hazardous - /

PBTZ169 is an antibiotic with antimycobacterial activity.{47066,47067} It is an irreversible inhibitor of DprE1, an essential enzyme for cell wall synthesis in mycobacteria.{47067} PBTZ169 is active against M. tuberculosis in vitro (MIC = ≤0.19 ng/ml) without inducing cytotoxicity in Vero cells when used at concentrations up to 125 µM.{47067,47066} It reduces the bacterial burden in the lung and spleen in a mouse model of chronic tuberculosis when administered at a dose of 50 mg/kg per day.  

 

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Description

An antibiotic with antimycobacterial activity; an irreversible inhibitor of DprE1; active against M. tuberculosis in vitro (MIC = ≤0.19 ng/ml) without inducing cytotoxicity in Vero cells at 125 µM; reduces the bacterial burden in the lung and spleen in a mouse model of chronic tuberculosis at 50 mg/kg per day

Formal name: 2-[4-(cyclohexylmethyl)-1-piperazinyl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

Synonyms: 

Molecular weight: 456.5

CAS: 1377239-83-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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