A reversible

PBIT – 5 mg

Brand:
Cayman
CAS:
2514-30-9
Storage:
-20
UN-No:
Non-Hazardous - /

Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively).{27801} It does not significantly affect the activity of UTX and JMJD3 demethylases.{27801} It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.{27801}  

 

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Description

A reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively); increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B

Formal name: 2-​(4-​methylphenyl)​-1,​2-benzisothiazol-​3(2H)​-​one

Synonyms:  2-​p-​tolyl-1,​2-​Benzisothiazolin-​3-​one

Molecular weight: 241.3

CAS: 2514-30-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Cancer||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation

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