A σ receptor ligand with anticancer and antiviral activites; binds to σ1 and σ2 receptors (Kis = 13 and 0.28 nM

PB 28 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
172907-03-8
Storage:
-20
UN-No:
Non-Hazardous - /

PB 28 is a sigma (σ) receptor ligand that binds to σ1 and σ2 receptors (Kis = 13 and 0.28 nM, respectively, in MCF-7 cell membranes) with anticancer and antiviral activities.{54391,55024} It is selective for σ1 and σ2 receptors over human ether-a-go-go (hERG) channels (Ki = 1,000 nM).{55024} PB 28 inhibits growth of MCF-7 and multidrug-resistant MCF-7/adr cells (IC50s = 25 and 15 nM, respectively).{54391} It also decreases basal P-glycoprotein (P-gp) levels in the same cells. PB 28 reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity in Vero E6 cells (IC90 = 278 nM), which is 20 times more potent than hydroxychloroquine (Item No. 17911).{55024}  

 

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SKU: 31742 - 10 mg Category:

Description

A σ receptor ligand with anticancer and antiviral activites; binds to σ1 and σ2 receptors (Kis = 13 and 0.28 nM, respectively, in MCF-7 cell membranes); selective for σ1 and σ2 receptors over hERG channels (Ki = 1,000 nM); inhibits growth of MCF-7 and multidrug-resistant MCF-7/adr cells (IC50s = 25 and 15 nM, respectively); decreases basal P-gp levels in the same cells; reduces SARS-CoV-2 infectivity in Vero E6 cells (IC90 = 278 nM)

Formal name: 1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-piperazine, dihydrochloride

Synonyms: 

Molecular weight: 443.5

CAS: 172907-03-8

Purity: ≥98%

Formulation: A crystalline solid

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