An orally bioavailable

Paritaprevir – 5 mg

Brand:
Cayman
CAS:
1216941-48-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Paritaprevir is an orally bioavailable, direct-acting inhibitor of the hepatitis C virus (HCV) non-structural 3/4A (NS3/4A) serine protease.{45394} It inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 3a, 4a, and 6a (EC50s = 1, 0.21, 5.3, 19, 0.09, and 0.69 nM, respectively). It also inhibits replicons from clinical isolates of genotypes 1a (EC50s = 0.43-1.87 nM) and 1b (EC50s = 0.033-0.087 nM). Formulations containing paritaprevir in combination with ombitasvir, ritonavir, and dasabuvir with and without ribavirin have been used in the treatment of chronic HCV genotype 1 infection.  

 

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SKU: 28301 - 5 mg Category:

Description

An orally bioavailable, direct-acting inhibitor of HCV NS3/4A serine protease; inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 3a, 4a, and 6a (EC50s = 1, 0.21, 5.3, 19, 0.09, and 0.69 nM, respectively); inhibits replicons from clinical isolates of genotypes 1a (EC50s = 0.43 to 1.87 nM) and 1b (EC50s = 0.033 to 0.087 nM)

Formal name: (2R,6S,12Z,13aS,14aR,16aS)-N-(cyclopropylsulfonyl)-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydro-6-[[(5-methyl-2-pyrazinyl)carbonyl]amino]-5,16-dioxo-2-(6-phenanthridinyloxy)-cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide

Synonyms:  ABT-450

Molecular weight: 765.9

CAS: 1216941-48-8

Purity: ≥98%

Formulation: A solid

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