A phenolic glycoside; prevents Aβ42-induced inhibition of NMDAR currents in rat hippocampal neurons at 2 μM; prevents Aβ42-induced inhibition of LTP in rats at 20 mg/kg; a 5-HT1A receptor agonist (Ki = 1.54 nM; EC50 = 34 nM for [35S]GTPγS binding); reverses phencyclidine-induced increases in immobility time in the forced swim test

Parishin C – 10 mg

Brand:
Cayman
CAS:
174972-80-6
Storage:
-20
UN-No:
Non-Hazardous - /

Parishin C is a phenolic glycoside and a major component of G. elata.{41985,41986} It prevents inhibition of NMDA receptor (NMDAR) currents induced by amyloid-β (1-42) (Aβ42) in rat hippocampal neurons when used at a concentration of 2 μM.{41985} In vivo, parishin C (20 mg/kg) prevents Aβ42-induced inhibition of long-term potentiation (LTP) in rats. Parishin is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 1.54 nM; EC50 = 34 nM for [35S]GTPγS binding) that reverses phencyclidine-induced increases in immobility time in the forced swim test, phencyclidine-induced decreases in interaction time in the social interaction test, and phencyclidine-induced impairments in visual recognition of a novel object in mice.{41986}  

 

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SKU: 25127 - 10 mg Category:

Description

A phenolic glycoside; prevents Aβ42-induced inhibition of NMDAR currents in rat hippocampal neurons at 2 μM; prevents Aβ42-induced inhibition of LTP in rats at 20 mg/kg; a 5-HT1A receptor agonist (Ki = 1.54 nM; EC50 = 34 nM for [35S]GTPγS binding); reverses phencyclidine-induced increases in immobility time in the forced swim test, phencyclidine-induced decreases in interaction time in the social interaction test, and reverses phencyclidine-induced impairments in visual recognition of a novel object in mice

Formal name: 3-carboxy-3-hydroxy-1,5-dioxo-1,5-pentanediylbis(oxymethylene-4,1-phenylene) bis-β-D-glucopyranoside

Synonyms: 

Molecular weight: 728.7

CAS: 174972-80-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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