A synthetic vitamin D2 analog; used in renal patients to block parathyroid hormone overproduction

Paricalcitol – 500 µg

Brand:
Cayman
CAS:
131918-61-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

1,25-Dihydroxy vitamin D2 (Item No. 11174) is a potent agonist of the vitamin D receptor.{20502,20503} Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction.{28966,28967,28969} Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.{28968}  

 

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Description

A synthetic vitamin D2 analog; used in renal patients to block parathyroid hormone overproduction

Formal name: (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-1,3-cyclohexanediol

Synonyms:  19-nor-1,25-Dihydroxyvitamin D2|1α,25-Dihydroxy-19-nor-vitamin D2|Zemplar

Molecular weight: 416.6

CAS: 131918-61-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease|Chronic Kidney Disease||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor

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