A peptide agonist of PAR4; activates PAR4 and the cleavage site mutant PAR4R47A at 500 µM; induces platelet aggregation of isolated washed human platelets at 1 mM but does not affect clotting time ex vivo

PAR4 (1-6) (human) – 5 mg

Brand:
Cayman
CAS:
225779-44-2
Storage:
-20
UN-No:
Non-Hazardous - /

PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence.{47423} It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 µM.{47424} PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.{47425}  

 

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SKU: 27126 - 5 mg Category:

Description

A peptide agonist of PAR4; activates PAR4 and the cleavage site mutant PAR4R47A at 500 µM; induces platelet aggregation of isolated washed human platelets at 1 mM but does not affect clotting time ex vivo

Formal name: glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine

Synonyms:  GYPGQV

Molecular weight: 619.7

CAS: 225779-44-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis

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