A peptide agonist of PAR2; induces relaxation in precontracted rat arteries; inhibits keratinocyte growth in the presence and absence of growth factors; inhibits LPS-induced pulmonary neutrophil influx and increases in MMP-2 activity in mice

PAR2 (1-6) (mouse, rat) – 5 mg

Brand:
Cayman
CAS:
164081-25-8
Storage:
-20
UN-No:
Non-Hazardous - /

PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6) induces relaxation in precontracted rat arteries in a concentration-dependent manner, an effect that can be reduced by the nitric oxide synthase inhibitor L-NNA (Item No. 80220).{45206} It inhibits keratinocyte growth in the presence and absence of growth factors.{45207} PAR2 (1-6) inhibits LPS-induced pulmonary neutrophil influx and increases in matrix metalloproteinase-2 (MMP-2) activity in mice.{45208}  

 

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SKU: 27125 - 5 mg Category:

Description

A peptide agonist of PAR2; induces relaxation in precontracted rat arteries; inhibits keratinocyte growth in the presence and absence of growth factors; inhibits LPS-induced pulmonary neutrophil influx and increases in MMP-2 activity in mice

Formal name: L-seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucine

Synonyms:  SLIGRL

Molecular weight: 657.8

CAS: 164081-25-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation

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