A proton pump inhibitor; inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles (IC50 = 6.8 µM); reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg); inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg); inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg)

Pantoprazole – 1 g

Brand:
Cayman
CAS:
102625-70-7
Storage:
-20
UN-No:
Non-Hazardous - /

Pantoprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles with an IC50 value of 6.8 µM.{33533} It reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg) and inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg).{48468} Pantoprazole inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg). Formulations containing pantoprazole have been used in the treatment of gastroesophageal reflux disease (GERD) and hypersecretory conditions, including Zollinger-Ellison Syndrome.  

 

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Description

A proton pump inhibitor; inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles (IC50 = 6.8 µM); reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg); inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg); inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg)

Formal name: 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

Synonyms:  BY 1023|SKF 96022

Molecular weight: 383.4

CAS: 102625-70-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers

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