A potent inhibitor of all HDACs

Panobinostat – 25 mg

Brand:
Cayman
CAS:
404950-80-7
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Panobinostat is a potent inhibitor of all histone deacetylases (HDACs), with Ki values ranging from 0.6 to 31 nM for HDAC1-11.{19767,24321} Through this action, it leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells.{24321} It has potential applications in several different forms of cancer as well as in spinal muscular atrophy and HIV therapy.{24321,24319,24322,24320}  

 

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Description

A potent inhibitor of all HDACs, with Ki values ranging from 0.6 to 31 nM for HDAC1-11; leads to acetylation of a range of cellular proteins, resulting in cell cycle arrest and apoptosis in cancer cells; has potential applications in spinal muscular atrophy and HIV therapy

Formal name: (2E)-N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide

Synonyms:  LBH-589

Molecular weight: 349.4

CAS: 404950-80-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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