Description
An agonist of NPY receptors; reduces forskolin-induced cAMP accumulation in L-M(TK-) cells recombinantly expressing human and rat Y4 receptors (EC50s = 87.1 and 36.3 pM, respectively); binds to human Y1 and Y5 receptors (Kis = 19 and 3.9 nM, respectively); induces contractile responses in isolated rat colon (EC50s = 1.6 and 0.7 nM for ascending and descending colon segments, respectively); increases food intake in rats (0.7-7 nmol, i.c.v.)
Formal name: L-alanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-prolyl-L-valyl-L-tyrosyl-L-prolylglycyl-L-α-aspartyl-L-asparaginyl-L-alanyl-L-threonyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-methionyl-L-alanyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-alanyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-tyrosyl-L-isoleucyl-L-asparaginyl-L-methionyl-L-leucyl-L-threonyl-L-arginyl-L-prolyl-L-arginyl-L-tyrosinamide, trifluoroacetate salt
Synonyms:
Molecular weight: 4,181.80
CAS: 75976-10-2
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake
