An FPP synthase inhibitor (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase

Pamidronate (sodium salt) – 50 mg

Brand:
Cayman
CAS:
57248-88-1
Storage:
-20
UN-No:
Non-Hazardous - /

Pamidronate is an amino bisphosphonate that inhibits farnesyl pyrophosphate (FPP) synthase (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively).{41320} In rats, it inhibits bone resorption when used at doses of 16 µmol/kg per day, impairs long bone growth at ≥40 µmol/kg per day, and has anti-hypercalcemic effects in a rat hypercalcemia model.{41318,41317} At high concentrations, pamidronate induces activation of matrix metalloproteinase-2 (MMP-2), NF-κB, and caspase-3, leading to cell death, which can be prevented by activated protein C.{41319} Formulations containing pamidronate have been used to treat hypercalcemia, Paget’s disease, metastatic bone disease, and multiple myeloma.  

 

Available on backorder

Add to quotes
SKU: 23699 - 50 mg Category:

Description

An FPP synthase inhibitor (IC50s = 0.85 and 0.20 µM in J774 cells and for human recombinant FPP synthase, respectively); inhibits bone resorption in rats when used at doses of 16 µmol/kg per day and impairs long bone growth at ≥40 µmol/kg per day; has anti-hypercalcemic effects in a rat hypercalcemia model; high concentrations induce activation of MMP-2, NF-κB, and caspase-3, leading to cell death

Formal name: P,P’-(3-amino-1-hydroxypropylidene)bis-phosphonic acid, disodium salt

Synonyms:  APD|CGP 23339A|Pamidronic Acid

Molecular weight: 279

CAS: 57248-88-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

Related products

  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 5 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 5 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 25 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 100 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page