An alkaloid with diverse biological activities; inhibits AChE and BChE (IC50s = 0.51 and 6.84 µM

Palmatine (chloride) – 1 g

Brand:
Cayman
CAS:
10605-02-4
Storage:
-20
UN-No:
Non-Hazardous - /

Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities.{47685,52524,52525,52526,52527} It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 µM, respectively).{47685} Palmatine (20, 40, and 80 µM) reduces Zika virus infection of Vero cells in a concentration-dependent manner.{52524} In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{52525} It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers.{52526} Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.{52527}  

 

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SKU: 30318 - 1 g Category:

Description

An alkaloid with diverse biological activities; inhibits AChE and BChE (IC50s = 0.51 and 6.84 µM, respectively); reduces Zika virus infection of Vero cells at 20, 40, and 80 µM; reduces colonic MPO activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of DSS-induced colitis; reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers; reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia at 10 and 20 mg/kg

Formal name: 5,6-dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium, monochloride

Synonyms: 

Molecular weight: 387.9

CAS: 10605-02-4

Purity: ≥98%

Formulation: A crystalline solid

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