An atypical antipsychotic; an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM

Paliperidone – 100 mg

Brand:
Cayman
CAS:
144598-75-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Paliperidone is an atypical antipsychotic.{42913} It is an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively), as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively).{25512} Paliperidone also binds to α1- and α2-adrenergic receptors, histamine H1 receptors, and the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively).{25511} It improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia when administered at a dose of 0.05 mg/kg per day.{42913} Paliperidone is also an active metabolite of the atypical antipsychotic risperidone (Item No. 13629).{25511} Formulations containing paliperidone have been used in the treatment of schizophrenia and schizoaffective disorder.  

 

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An atypical antipsychotic; an inverse agonist of dopamine D2 and D3 receptors (IC50s = 1 and 0.9 nM, respectively) as well as an antagonist at these receptors (Kis = 0.4 and 0.1 nM, respectively); binds to α1- and α2-adrenergic receptors, histamine H1 receptors, and the 5-HT receptor subtypes 5-HT1A , 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 10.1, 80, 3.4, 480, 19, 1.21, and 48 nM, respectively); improves spatial working memory in a T-maze alternation task in a maternal immune activation mouse model of schizophrenia at 0.05 mg/kg per day; an active metabolite of risperidone,,

Formal name: 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Synonyms:  9-hydroxy Risperidone|RO76477

Molecular weight: 426.5

CAS: 144598-75-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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