Immunogen: Synthetic peptide from the internal region of human PAF receptor • Host: Mouse

PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21) – 1 ea

Brand:
Cayman
Storage:

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.{5109,5148,5150,5145,5149} Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain.{5150,5145} In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor.{4226} Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.{4225}  

 

Available on backorder

Add to quotes
SKU: 160600 - 1 ea Category:

Description

Immunogen: Synthetic peptide from the internal region of human PAF receptor • Host: Mouse, 11A4 clone 21 • Species Reactivity: (+) Human, bovine, and porcine PAF receptor • Isotype: IgG2a • Application(s): ELISA, FC, and ICC; does not work for WB • PAF is a biologically active phospholipid whose biological effects include activation of platelets, polymorphonuclear leukocytes, monocytes, and macrophages. PAF increases vascular permeability, decreases cardiac output, induces hypotension, and stimulates uterine contraction.

Synonyms: Platelet-activating Factor Receptor

Immunogen: Synthetic peptide from the internal region of human PAF receptor

Formulation: 100 µg of Protein A-purified monoclonal antibody

Isotype: IgG2a

Applications: (+) ELISA, FC, and ICC; (−) WB

Origin: Animal/Mouse

Stability: 730 days

Application|ELISA||Application|Flow Cytometry||Application|Immunocytochemistry||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Glycerophospholipids

Related products