A naturally occurring phospholipid produced by cells upon inflammatory stimulation; less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis

PAF C-18:1 – 5 mg

Brand:
Cayman
CAS:
85966-90-1
Storage:
-20
UN-No:
De Minimis - 1170 / 3

PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 (Item No. 60900) and PAF C-18 (Item No. 60910) in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration.{1437,30475} PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recognition at this receptor.{1629}  

 

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Description

A naturally occurring phospholipid produced by cells upon inflammatory stimulation; less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration

Formal name: 7R-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacos-18Z-en-1-aminium, 4-oxide inner salt

Synonyms:  1-Oleoyl-2-acetyl-sn-glycero-3-phosphorylcholine|Platelet-activating Factor C-18:1

Molecular weight: 549.7

CAS: 85966-90-1

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Glycerophospholipids||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids

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