A phenol with diverse biological activities; inhibits LPS- and IFN-γ-induced migration and production of ROS in BV-2 microglia at 10 and 30 µM; inhibits compound 48/80-induced histamine release from rat peritoneal mast cells; reduces mortality in a mouse model of compound 48/80-induced anaphylactic shock at 0.5 mg/animal; reduces hepatic necrosis and serum levels of ALT and AST in a mouse model of acetaminophen-induced hepatotoxicity at 100 mg/kg; inhibits carrageenan-induced thermal hyperalgesia and production of NO and PGE2 in rats at 30

Paeonol – 10 g

Brand:
Cayman
CAS:
552-41-0
Storage:
22
UN-No:
Non-Hazardous - /

Paeonol is a phenol that has been found in Paeonia and has diverse biological activities.{31764,58139,31762,31761} It inhibits LPS- and IFN-γ-induced migration and production of reactive oxygen species (ROS) in BV-2 microglia when used at concentrations of 10 and 30 µM.{31764} Paeonol inhibits histamine release from rat peritoneal mast cells induced by compound 48/80 (Item No. 22173) and reduces mortality in a mouse model of compound 48/80-induced anaphylactic shock when administered at a dose of 0.5 mg per animal.{58139} It reduces hepatic necrosis and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a mouse model of hepatotoxicity induced by acetaminophen (Item No. 10024) when administered at a dose of 100 mg/kg.{31762} Paeonol (30, 50, and 100 mg/kg) inhibits carrageenan-induced thermal hyperalgesia and production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in rats.{31761}  

 

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Description

A phenol with diverse biological activities; inhibits LPS- and IFN-γ-induced migration and production of ROS in BV-2 microglia at 10 and 30 µM; inhibits compound 48/80-induced histamine release from rat peritoneal mast cells; reduces mortality in a mouse model of compound 48/80-induced anaphylactic shock at 0.5 mg/animal; reduces hepatic necrosis and serum levels of ALT and AST in a mouse model of acetaminophen-induced hepatotoxicity at 100 mg/kg; inhibits carrageenan-induced thermal hyperalgesia and production of NO and PGE2 in rats at 30, 50, and 100 mg/kg

Formal name: 1-(2-hydroxy-4-methoxyphenyl)-ethanone

Synonyms:  2′-Hydroxy-4′-methoxyacetophenone|NSC 401442

Molecular weight: 166.2

CAS: 552-41-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Death|Necrosis||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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