Description
Protein arginine deiminases (PADs) are guanidine-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4, and PAD6. PADs are calcium-dependent enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline.{19489, 18141} The excess deimination of target proteins can result in the production of anti-citrullinated protein antibodies (ACPAs) which can be indicators of a number of disease states.{31883} The various PADs exhibit tissue specific expression and different subcellular localization.{19488} PAD1 is expressed in uterus and throughout the epidermis. PAD1 and PAD3 are speculated to mediate deamination of epidermal filaggrin (filament aggregation protein) and keratins, proteins involved in maintaining skin hydration.{19490} The predicted size for PAD1 is 74.7 kD and Cayman’s PAD1 monoclonal antibody (clone 6B4) detects a band at ~74 kD by Western blot.
Synonyms: PADI1|PDI1|Peptidylarginine Deiminase 1|Protein Arginine Deiminase 1
Immunogen: Recombinant human PAD1 protein
Formulation: 100 µg of protein G-purified antibody
Isotype: IgG2b
Applications: ELISA and WB
Origin:
Stability: 365 days
Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area
