Immunogen: Recombinant human PAD1 protein • Clone designation: 6B4 • Host: Mouse • Cross Reactivity: (-) PAD2

PAD1 Monoclonal Antibody (Clone 6B4) – 100 µg

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Cayman
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Protein arginine deiminases (PADs) are guanidine-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4, and PAD6. PADs are calcium-dependent enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline.{19489, 18141} The excess deimination of target proteins can result in the production of anti-citrullinated protein antibodies (ACPAs) which can be indicators of a number of disease states.{31883} The various PADs exhibit tissue specific expression and different subcellular localization.{19488} PAD1 is expressed in uterus and throughout the epidermis. PAD1 and PAD3 are speculated to mediate deamination of epidermal filaggrin (filament aggregation protein) and keratins, proteins involved in maintaining skin hydration.{19490} The predicted size for PAD1 is 74.7 kD and Cayman’s PAD1 monoclonal antibody (clone 6B4) detects a band at ~74 kD by Western blot.  

 

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SKU: 22997 - 100 µg Category:

Description

Immunogen: Recombinant human PAD1 protein • Clone designation: 6B4 • Host: Mouse • Cross Reactivity: (-) PAD2, PAD3, and PAD4 • Species Reactivity: (+) Human • Isotype: IgG2b • Applications: ELISA and WB

Synonyms: PADI1|PDI1|Peptidylarginine Deiminase 1|Protein Arginine Deiminase 1

Immunogen: Recombinant human PAD1 protein

Formulation: 100 µg of protein G-purified antibody

Isotype: IgG2b

Applications: ELISA and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area

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