A prodrug form of paclitaxel; comprised of paclitaxel conjugated to 1

Paclitaxel octadecanedioate – 1 mg

Brand:
Cayman
CAS:
2089211-45-8
Storage:
-20
UN-No:
Non-Hazardous - /

Paclitaxel octadecanedioate is a prodrug form of paclitaxel (Item No. 10461) that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.{50209} Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner.  

 

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SKU: 28635 - 1 mg Category:

Description

A prodrug form of paclitaxel; comprised of paclitaxel conjugated to 1,18-octadecanedioic acid; does not promote tubulin polymerization in vitro at 10 μM; cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50 = 12, 2.48, and 8.62 nM, respectively) as a 5:1 mixture with HSA; mixture with HSA reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner

Formal name: octadecanedioic acid-1-[(1R,2S)-2-(benzoylamino)-1-[[[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl] ester

Synonyms:  1,18-Octadecanedioic Acid-Paclitaxel|ODDA-PTX|PTX-FA18

Molecular weight: 1,150.40

CAS: 2089211-45-8

Purity: ≥98%

Formulation: A crystalline solid

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