A procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3; exhibits an IC50 value of 3 nM for induction of cancer cell death without affecting non-cancerous cells

PAC-1 – 50 mg

Brand:
Cayman
CAS:
315183-21-2
Storage:
-20
UN-No:
Non-Hazardous - /

Apoptosis can be induced when procaspase-3 is activated and converted to caspase-3. Procaspase-activating compound 1 (PAC-1) is a procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3.{14401} PAC-1’s effectiveness was found to be directly proportional to the procaspase-3 concentration present in cells. In cancer cells, PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue IC50 values of 3.2-8.5 µM were observed.{14401}  

 

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SKU: 10009317 - 50 mg Category:

Description

A procaspase-3 activator and a potential drug treatment in cancer cell lines with elevated levels of procaspase-3; exhibits an IC50 value of 3 nM for induction of cancer cell death without affecting non-cancerous cells

Formal name: 4-(phenylmethyl)-1-piperazineacetic acid, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

Synonyms:  Procaspase-activating Compound 1

Molecular weight: 392.5

CAS: 315183-21-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Caspases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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