A first-in-class inhibitor of HIV-1 maturation

PA-457 – 10 mg

Brand:
Cayman
CAS:
174022-42-5
Storage:
-20
UN-No:
Non-Hazardous - /

PA-457 is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.{33662,33663,33664} Specific inhibition of this final rate-limiting step in Gag processing results in the production of immature, non-infectious virus particles.{33662} PA-457 reduced viral load in HIV-infected adults in a dose-dependent fashion, when given in a single oral dose in a clinical study.{33663} It is inactive against HIV-2 or Simian immunodeficiency virus.{33664}  

 

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Description

A first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation

Formal name: (3β)-3-(3-carboxy-3-methyl-1-oxobutoxy)-lup-20(29)-en-28-oic acid

Synonyms:  Bevirimat|FH11327|MPC-4326

Molecular weight: 584.8

CAS: 174022-42-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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