An ATP-competitive inhibitor of p38 MAPKs; inhibits p38α

p38 MAPK Inhibitor IV – 10 mg

Brand:
Cayman
CAS:
1638-41-1
Storage:
-20
UN-No:
Non-Hazardous - /

p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38 , and p38δ, respectively, in vitro.{37130} It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.  

 

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Description

An ATP-competitive inhibitor of p38 MAPKs; inhibits p38α, p38β, p38 , and p38δ MAPKs (IC50s = 0.13, 0.55, 5.47, and 8.63 μM, respectively); inhibits LPS-induced TNF-α and IL-1β cytokine production in human peripheral blood mononuclear cells (IC50s = 22 and 44 nM, respectively)

Formal name: 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-phenol

Synonyms:  p38 MAP Kinase Inhibitor IV|p38 Mitogen-activated Protein Kinase Inhibitor IV

Molecular weight: 456.9

CAS: 1638-41-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|p38 MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|p38 MAPK Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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