A competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM); used to improve glucose tolerance

P32/98 (hemifumarate) – 1 mg

Brand:
Cayman
CAS:
251572-86-8
Storage:
-20
UN-No:
Non-Hazardous - /

The glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are responsible for a majority of nutrient-stimulated insulin secretion. After being released into the circulation, GIP and GLP-1 are inactivated by the circulating enzyme dipeptidyl peptidase IV (DPP IV). DPP IV inhibitors have emerged as a new class of experimental antidiabetic agents. P32/98 is a competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM).{24373} At 20 mg/kg/day, it has been used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models.{27894}  

 

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Description

A competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM); used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models at 20 mg/kg/day

Formal name: (2S,3S)-2-amino-3-methyl-1-(3-thiazolidinyl)-1-pentanone, 2E-butenedioate (2:1)

Synonyms: 

Molecular weight: 260.4

CAS: 251572-86-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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