Description
A dual inhibitor of USP7 and USP47 (EC50s = 8.01 and 8.74 µM, respectively); selective for USP7 and USP47 over other USPs and proteases with EC50 values greater than 50 µM; induces the accumulation of polyubiquitinated proteins in HEK293 cells when used at a concentration of 25 µM; amplifies the cytotoxicity and p53-mediated apoptosis of doxorubicin of doxorubicin and etoposide in neuroblastoma cells when used at concentrations of 10 and 20 µM; inhibits tumor growth in neuroblastoma mouse xenograft models when administered at a dose of 20 mg/kg per day
Formal name: 1-[5-[(2,4-difluorophenyl)thio]-4-nitro-2-thienyl]-ethanone
Synonyms:
Molecular weight: 315.3
CAS: 1247819-59-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System
