A tetracycline antibiotic; active against S. aureus

P005672 (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
1035979-44-2
Storage:
-20
UN-No:
Non-Hazardous - /

P005672 is a tetracycline antibiotic that has activity against S. aureus RN450, S. pneumoniae 157E-strep, P. acnes ATCC 6919 and ATCC 11827, E. coli ATCC 25922 and MG 1655, and B. thetaiotaomicron, in vitro, when used at concentrations less than or equal to 8 μg/ml.{36678} It is non-cytotoxic to COS-1 and CHO cells (IC50 = >75 μg/ml for both) and is less phototoxic to 3T3 fibroblasts than doxycycline (Item No. 14422; IC50s = >25 and In vivo, P005672 increases survival in a mouse model of lethal S. aureus RN450 infection with a protective dose (PD50) value of 0.13 mg/kg. It also reduces paw edema in a rat model of carrageenan-induced inflammation.  

 

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SKU: 24685 - 25 mg Category:

Description

A tetracycline antibiotic; active against S. aureus, S. pneumoniae, P. acnes, E. coli, and B. thetaiotaomicron, in vitro, at less than or equal to 8 μg/ml; non-cytotoxic to COS-1 and CHO cells (IC50 = >75 μg/ml for both); less phototoxic to 3T3 fibroblasts than doxycycline (IC50s = >25 and S. aureus RN450 infection (PD50 = 0.13 mg/kg); reduces paw edema in a rat model of carrageenan-induced inflammation

Formal name: (4S,4aS,5aR,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride

Synonyms:  Sarecycline|WC 3035

Molecular weight: 524

CAS: 1035979-44-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Tetracyclines||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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