A cell-permeable analog of pifithrin-α that blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α; suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet

p-nitro-Pifithrin-α – 5 mg

Brand:
Cayman
CAS:
389850-21-9
Storage:
-20
UN-No:
Non-Hazardous - /

Pifithrin-α (Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.{17259} p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α.{23578} It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α.{23578} p-nitro-Pifithrin-α, at 10 µM, suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet.{26427,26428} It is slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-α, when incubated in biological media (t½ = 8 h).{23578}  

 

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Description

A cell-permeable analog of pifithrin-α that blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α; suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet

Formal name: 1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide

Synonyms:  p-nitro-PFT-α

Molecular weight: 398.3

CAS: 389850-21-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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