A cell-permeable form of cyclic PFT-α; 10-fold more active that PFT-α in protecting cortical neurons exposed to etoposide (ED50 = 30 nM); not active in vivo

p-nitro-Cyclic Pifithrin-α – 5 mg

Brand:
Cayman
CAS:
60477-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

Pifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.{17259} Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α.{23585} p-nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α.{23578} It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed to etoposide (ED50 = 30 nM).{23578} p-nitro-Cyclic PFT-α acts in a p53-dependent manner but does not block phosphorylation of p53 on Ser15 in response to etoposide treatment, although it prevents p53 posttranscriptional activity.{23578} Although it is more stable in solution than the parent compound, this derivative is not active in vivo.{23578}  

 

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Description

A cell-permeable form of cyclic PFT-α; 10-fold more active that PFT-α in protecting cortical neurons exposed to etoposide (ED50 = 30 nM); not active in vivo

Formal name: 5,6,7,8-tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole

Synonyms:  p-nitro-Cyclic PFT-α|Cyclic pifithrin-α-p-nitro

Molecular weight: 299.3

CAS: 60477-38-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Neuroscience

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