A partial agonist of the α2-adrenergic receptor

p-iodo-Clonidine (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
108294-57-1
Storage:
-20
UN-No:
Non-Hazardous - /

Clonidine (Item No. 15949) is an antihypertensive α2-adrenergic receptor agonist. p-iodo-Clonidine is a partial agonist of the α2-adrenergic receptor, minimally inhibiting adenylate cyclase through this Gi protein-coupled receptor although it binds avidly (Ki = 1.0 nM).{28190} It potentiates platelet aggregation by ADP (EC50 = 1.5 µM) and inhibits epinephrine-induced aggregation (IC50 = 5.1 µM).{28190}  

 

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Description

A partial agonist of the α2-adrenergic receptor, minimally inhibiting adenylate cyclase through this Gi protein-coupled receptor although it binds avidly (Ki = 1.0 nM); potentiates platelet aggregation by ADP (EC50 = 1.5 µM) and inhibits epinephrine-induced aggregation (IC50 = 5.1 µM)

Formal name: N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride

Synonyms: 

Molecular weight: 392.5

CAS: 108294-57-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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