A sulfate conjugate of p-cresol; increases migration and proliferation of isolated rat aortic VSMCs at 500 µM; increases aortic atherosclerotic plaques lesion area in nephrectomized ApoE-/- mice fed a high-fat diet when administered at 100 mg/kg per day via the drinking water; serum levels are increased in patients with advanced stage chronic kidney disease and positively associated with vascular calcification

p-Cresol sulfate (potassium salt) – 1 g

Brand:
Cayman
CAS:
91978-69-7
Storage:
-20
UN-No:
Non-Hazardous - /

p-Cresol sulfate is a sulfate conjugate of the uremic toxin p-cresol, which is formed by bacterial fermentation of proteins in the large intestine.{45960,45961} p-Cresol sulfate increases migration and proliferation of isolated rat aortic vascular smooth muscle cells (VSMCs) when used at a concentration of 500 µM.{45962} It also increases the area of aortic atherosclerotic plaques in nephrectomized ApoE-/- mice fed a high-fat diet when administered at a dose of 100 mg/kg per day via the drinking water. Serum levels of total and free p-cresol sulfate are increased in patients with advanced stage chronic kidney disease and positively associated with vascular calcification.{45963}  

 

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SKU: 29504 - 1 g Category:

Description

A sulfate conjugate of p-cresol; increases migration and proliferation of isolated rat aortic VSMCs at 500 µM; increases aortic atherosclerotic plaques lesion area in nephrectomized ApoE-/- mice fed a high-fat diet when administered at 100 mg/kg per day via the drinking water; serum levels are increased in patients with advanced stage chronic kidney disease and positively associated with vascular calcification

Formal name: sulfuric acid, mono(4-methylphenyl) ester, monopotassium salt

Synonyms:  para-Cresol sulfate|4-Cresyl sulfate

Molecular weight: 226.3

CAS: 91978-69-7

Purity: ≥95%

Formulation: A solid

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