An inhibitor of tryptophan hydroxylase (Ki = 300 µM); a competitive inhibitor in vitro and an irreversible inhibitor in vivo; depletes serotonin to undetectable levels in rats after six days at 300 mg/kg; has commonly been used to deplete brain serotonin levels in animal studies of the serotonergic system

p-chloro Phenylalanine – 50 g

Brand:
Cayman
CAS:
7424-00-2
Storage:
-20
UN-No:
Limited Quantity - 2811 / 6.1

p-chloro Phenylalanine is an inhibitor of tryptophan hydroxylase (Ki = 300 µM).{47198} It acts as a competitive inhibitor in vitro and an irreversible inhibitor in vivo. It depletes serotonin to undetectable levels in rats after six days when administered at a dose of 300 mg/kg. p-chloro Phenylalanine has commonly been used to deplete brain serotonin levels in animal studies of the serotonergic system and its involvement in depressive-like behavior, reward learning, Parkinson’s disease, and pain.{47199,47200,47201,47202}  

 

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SKU: 26168 - 50 g Category:

Description

An inhibitor of tryptophan hydroxylase (Ki = 300 µM); a competitive inhibitor in vitro and an irreversible inhibitor in vivo; depletes serotonin to undetectable levels in rats after six days at 300 mg/kg; has commonly been used to deplete brain serotonin levels in animal studies of the serotonergic system

Formal name: 4-chloro-phenylalanine

Synonyms:  para-chloro Phenylalanine|4-chloro Phenylalanine|CP 10188|Fenclonine|NSC 77370|PCPA

Molecular weight: 199.6

CAS: 7424-00-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Pain Research

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